The Department of Radiation Oncology at UT Southwestern Medical Center is recruiting a senior Ph.D. scientist or M.D./Ph.D. physician-scientist to join the Molecular Medicine Section, a translational research unit focused on understanding and overcoming therapeutic resistance in cancer.

The section, under new leadership, has strong and growing programs in small molecule target identification and drug discovery. We are particularly interested in investigators developing new approaches for target identification using both chemical and genetic tools, including chemical probes, functional genomics, and CRISPR-based screening. These efforts are tightly integrated with mechanistic studies designed to reveal how both conventional and advanced forms of radiotherapy act on cancer cells and tissues. Candidates working at the interface of chemical biology, functional genomics, and translational oncology are especially encouraged to apply.

We seek an innovative and collaborative investigator who:

• Holds a Ph.D. (or M.D./Ph.D.) in chemistry, biology, biomedical engineering, or a related field
• Has completed 2–3 years of postdoctoral training
• Has expertise in chemical biology, target discovery, genetic screening, or related areas
• Is passionate about applying integrated chemical and genetic approaches to understand therapy mechanisms
• Possesses excellent communication, leadership, and problem-solving skills
• Values interdisciplinary collaboration and translational impact

Research Environment & Opportunities

UT Southwestern is one of the nation’s premier biomedical research institutions, home to six Nobel Laureates and 25 members of the National Academy of Sciences. The Department of Radiation Oncology is nationally recognized for innovation in clinical practice, radiation physics, and translational research.

The department includes:

• A high-volume clinical program with state-of-the-art radiotherapy platforms
• 25 physician-scientists, 14 residents, and a collaborative clinical faculty
• A Division of Medical Physics and Engineering with 31 faculty physicists and robust technical infrastructure
• A Molecular Medicine Section with 18 faculty (10 principal investigators) actively pursuing discovery-driven research

In our section and department, we are committed to building a dynamic and collaborative community of researchers focused on basic discoveries that will have a lasting impact on the care of cancer patients. New faculty will be supported with resources to build integrated research programs and encouraged to collaborate with colleagues across UT Southwestern, including within the Harold C. Simmons Comprehensive Cancer Center.

UT Southwestern Medical Center is committed to an educational and working environment that provides equal opportunity to all members of the University community.  As an equal opportunity employer, UT Southwestern prohibits unlawful discrimination, including discrimination on the basis of race, color, religion, national origin, sex, sexual orientation, gender identity, gender expression, age, disability, genetic information, citizenship status, or veteran status.

This position is security-sensitive and subject to Texas Education Code 51.215, which authorizes UT Southwestern to obtain criminal history record information.

Appointment rank will be commensurate with academic accomplishment and experience. Consideration may be given to applicants seeking less than a full-time schedule.

To learn more about the benefits UT Southwestern offers, visit https://www.utsouthwestern.edu/employees/hr-resources/