A postdoctoral training position is available in the laboratory of Daniel Kober in the department of Biochemistry at UT Southwestern Medical Center. The focus of the position is to carry out a high-throughput screen to identify, develop, and validate inhibitors of the Site-One Protease (S1P) / SPRING complex. Building on our recent publications in PNAS and Nature Communications (PMID: 40299693 and 38977690), the postdoc will screen for small molecule inhibitors of the complex and interrogate hits using established enzymatic and cell-based counter-screens. Computational screening methods may also be utilized. In parallel, the postdoc will develop new cell-based tools to interrogate the role of S1P and lead hits in cancer models.

More information about our lab can be found here: https://labs.utsouthwestern.edu/kober-lab.

• Candidates must hold a recent Ph.D. and/or M.D. degree
• Evidence of productivity demostrated in peer reviewed publications. 
• Be highly motivated, curious, and detail-oriented, and organized. The candidate must be capable of carrying out multiple research directions in parallel and integrating results from collaborators. 
• Works well in collaboration with a team while taking reponsibility for individual productivity. 

The ideal candidate will have experience in the following areas, but strong candidates who do not possess all these preferred skills are still encouraged to apply.

• Enzymology (e.g. kinetic assays, Michaelis-Menton analysis, inhibitor analysis). 

•           Expressing and purifying recombinant proteins.

•           Mammalian cell culture work, including using CRISPR-Cas9 to generate and characterize knockout cell lines.

•          Experience with modeling and interpreting protein-ligand structural data.

•          Experience using pre-clinical models of cancer (cells and/or animals).

To Apply:

Please submit a CV, a brief cover letter explaining interest, and the contact information for at least two (2) references to daniel.kober@utsouthwestern.edu

UT Southwestern Medical Center is committed to an educational and working environment that provides equal opportunity to all members of the University community.  As an equal opportunity employer, UT Southwestern prohibits unlawful discrimination, including discrimination on the basis of race, color, religion, national origin, sex, sexual orientation, gender identity, gender expression, age, disability, genetic information, citizenship status, or veteran status.

This position is security-sensitive and subject to Texas Education Code 51.215, which authorizes UT Southwestern to obtain criminal history record information.

Appointment rank will be commensurate with academic accomplishment and experience. Consideration may be given to applicants seeking less than a full-time schedule.

To learn more about the benefits UT Southwestern offers, visit https://www.utsouthwestern.edu/employees/hr-resources/