Position Overview

The Choi Laboratory is seeking a highly motivated and collaborative postdoctoral researcher to investigate how environmental signals and epigenetic programs shape pathogenic T-cell responses in autoimmune disease. Our research combines functional immunology with genomic and epigenomic approaches to uncover the mechanisms that drive systemic lupus erythematosus and other immune-mediated diseases.

The successful candidate will work alongside experimental, computational, and clinical collaborators to identify disease-driving pathways and translate mechanistic discoveries into new immune-modulating therapies. Projects will span fundamental T-cell biology, chromatin regulation, functional genomics, and therapeutic discovery, with the long-term goal of advancing promising treatments toward first-in-human studies at UT Southwestern.

This position is particularly well suited for researchers seeking rigorous scientific training at the intersection of immunology, epigenetics, genomics, and translational medicine, with preparation for careers in academia, biotechnology, pharmaceutical research, or therapeutic development.

Research Focus

The successful candidate will investigate the molecular and epigenetic mechanisms that regulate immune-cell behavior, with particular emphasis on:

• Environmental and epigenetic regulation of pathogenic T-cell responses
• T-cell biology and immune regulation in systemic lupus erythematosus and related autoimmune diseases
• Chromatin dynamics and transcriptional regulation in immune cells
• Epigenetic mechanisms relevant to autoimmune disease and neurodegeneration
• Translation of mechanistic discoveries into new immune-modulating therapies

Why Join the Choi Laboratory at UT Southwestern?

Members of the Choi Laboratory work at the interface of mechanistic discovery and therapeutic development. The laboratory’s autoimmune research program investigates the molecular mechanisms underlying pathogenic T cells in diseases such as systemic lupus erythematosus, using epigenetic approaches and functional screening to identify key transcriptional drivers and potential strategies for reprogramming harmful immune-cell states.

Through the Center for Cellular Therapies and Cancer Immunology, researchers work within a multidisciplinary environment that brings together immunologists and cell, protein, genome, and chemical engineers to develop effective and safe immunotherapies for cancer, autoimmune disease, and other conditions. The Center is specifically focused on translating promising discoveries into therapies that can progress toward first-in-human studies at UT Southwestern and beyond.

UT Southwestern provides postdoctoral researchers with access to advanced shared research resources, structured training, career-development programs, interdisciplinary collaboration, and comprehensive benefits. Postdoctoral scholars can also participate in certificate programs, professional-development workshops, entrepreneurial resources, and individualized career advising.

Candidates must hold a recent Ph.D. in Immunology, Molecular Biology, or related field. Experience with epigenetic techniques (ChIP-seq, ATAC-seq), strong background in molecular biology, proficiency in flow cytometry leading to publication in peer-reviewed journals is recommended. Preferred skills include experience with mouse models, bioinformatics skills (R, Python), background in T cell immunology, and a publication record in immunology/epigenetics.

Please read recent manuscripts published in the last two years.

Applicants should apply at https://jobs.utsouthwestern.edu/Search for Job # 966440

Information on our postdoctoral training program, benefits, and a virtual tour can be found at htt;s://www.utsouthwestern.edu/postdocs

UT Southwestern Medical Center is committed to an educational and working environment that provides equal opportunity to all members of the University community.  As an equal opportunity employer, UT Southwestern prohibits unlawful discrimination, including discrimination on the basis of race, color, religion, national origin, sex, sexual orientation, gender identity, gender expression, age, disability, genetic information, citizenship status, or veteran status.

This position is security-sensitive and subject to Texas Education Code 51.215, which authorizes UT Southwestern to obtain criminal history record information.

Appointment rank will be commensurate with academic accomplishment and experience. Consideration may be given to applicants seeking less than a full-time schedule.

To learn more about the benefits UT Southwestern offers, visit https://www.utsouthwestern.edu/employees/hr-resources/