A postdoctoral training position is available in the laboratory of Daniel Kober in the department of Biochemistry at UT Southwestern Medical Center. Our lab investigates the structural and functional basis for the maturation and activation of proprotein convertases (PCSKs), serine proteases in the secretory system that play important roles throughout physiology and metabolism. The postdoc will carry out mechanistic studies of PCSK activation and maturation using interdisciplinary structure-function approaches. Examples of our work in this field can be found in our recent publications in PNAS and Nature Communications (PMID: 40299693 and 38977690).

More information about our lab can be found here: https://labs.utsouthwestern.edu/kober-lab.

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• Candidates must hold a recent Ph.D. and/or M.D. degree
• Evidence of productivity demonstrated in peer reviewed publications.
• Be highly motivated, curious, detail-oriented, and organized. The candidate must be capable of carrying out multiple research directions in parallel and integrating results from collaborators.
• Works well in collaboration with a team while taking responsibility for individual productivity. 

The ideal candidate will have experience in the following areas, but strong candidates who do not possess all these preferred skills are still encouraged to apply.

•          Expressing, purifying, and characterizing recombinant enzymes.
•          Mammalian cell culture work, including using CRISPR-Cas9 to generate and characterize knockout cell lines.
•          Identifying and characterizing protein-protein interaction partners.
•      Experience with single-particle cryoEM data and/or interpreting structural models is advantageous but not required. 

To Apply:

Please submit a CV, a brief cover letter explaining interest, and the contact information for at least two (2) references to daniel.kober@utsouthwestern.edu

UT Southwestern Medical Center is committed to an educational and working environment that provides equal opportunity to all members of the University community.  As an equal opportunity employer, UT Southwestern prohibits unlawful discrimination, including discrimination on the basis of race, color, religion, national origin, sex, sexual orientation, gender identity, gender expression, age, disability, genetic information, citizenship status, or veteran status.

This position is security-sensitive and subject to Texas Education Code 51.215, which authorizes UT Southwestern to obtain criminal history record information.

Appointment rank will be commensurate with academic accomplishment and experience. Consideration may be given to applicants seeking less than a full-time schedule.

To learn more about the benefits UT Southwestern offers, visit https://www.utsouthwestern.edu/employees/hr-resources/